Rice University chemists have developed an eco-friendly method for incorporating chlorine into chemical compounds used in medications, plastics and pesticides, according to a news release. Published in Nature Synthesis on Jan. 2, the process uses iron and sulfur catalysts activated by blue light to add chlorine atoms to organic molecules at room temperature. This approach, led by Julian West, eliminates the need for harsh chemicals and high temperatures typically required in chlorination.
The method achieves precise chlorine placement through anti-Markovnikov hydrochlorination, resulting in highly pure products and reducing purification steps. Additionally, the team discovered that using heavy water to incorporate deuterium could enhance drug stability in the body.
The innovation offers several advantages: sustainable catalysts, room-temperature operation, targeted chlorination and reduced purification requirements.
“It’s exciting that this method could open new doors for modifying pharmaceuticals and natural products in ways that weren’t possible with older techniques,” West said.
