EMD Millipore Introduces Single-Pass TFF System With Pellicon Cassettes

EMD Millipore, the life science business of Merck KGaA, introduces single-pass tangential flow filtration (TFF) with Pellicon cassettes, an enhanced application of EMD Millipore's existing TFF technology that allows concentration of process streams without the recirculation required in traditional TFF, according to the company. The alternative application reportedly eliminates typical process constraints caused by higher volumes or concentration factors, resulting in increased capacity. It also enables continuous processing by coupling the TFF step in-line with other process steps, according to EMD Millipore.

EMD Millipore's single-pass TFF system uses Pellicon cassettes, which are TFF devices suited for higher titer therapeutic antibodies as well as more demanding filtration processes that require higher operating pressures, temperatures, concentrations or caustic cleaning regimes.